Didelphis virginiana, commonly known as the Virginia opossum, is native to North America. Its geographical distribution extends from southern Canada through the United States and into the northern regions of Mexico. The opossum has been introduced and is now found in other parts of North America as well.

The Virginia opossum is highly adaptable and occupies a wide range of habitats. Typically, it thrives in temperate and subtropical climates with sufficient access to water and food sources. It is commonly found in wooded areas, farmlands, and urban environments where it can find shelter in abandoned structures or dense vegetation.

As an opportunistic omnivore, the Virginia opossum plays a significant role in its ecosystem by controlling insect and small vertebrate populations, as well as scavenging carrion. Its adaptability allows it to exploit various food sources, including fruits, grains, small animals, and human refuse. The opossum is also noted for its resistance to venom from certain snakes, giving it a unique position in certain ecosystems.