Hemidactylus mabouia, commonly known as the Tropical House Gecko, is originally native to sub-Saharan Africa. It is widely distributed across the African continent, particularly in West Africa and Central Africa.

Hemidactylus mabouia thrives in warm, tropical environments. It is often found in human-modified habitats, including urban and suburban areas, where it can live in close proximity to human dwellings. This gecko prefers warm temperatures and is highly adaptable to various environmental conditions as long as the climate remains temperate to tropical.

The Tropical House Gecko is primarily insectivorous, feeding on insects and other smaller arthropods. It occupies a nocturnal niche, being most active during the night, which helps it avoid predators and adapt to urban lighting conditions. Hemidactylus mabouia is commonly found on walls, ceilings, and other structures where insects are plentiful, allowing it to thrive in human-altered environments.