Lithobates palustris, commonly known as the Pickerel Frog, is native to North America. It primarily occurs in eastern and central regions of the United States. Its range extends from southeastern Canada through the Dakotas, south to Texas, and eastward to the Atlantic coast, excluding the Florida peninsula.

Pickerel Frogs are typically found in cool, clear waters. They inhabit various wetland environments, including ponds, marshes, slow-moving streams, and springs. These frogs prefer areas with abundant vegetation and are often found in wooded or partially shaded regions.

The aquatic and semi-aquatic habitats of Lithobates palustris offer them a suitable environment for breeding and foraging. They consume a diet of invertebrates, including insects and spiders, thus playing a role in controlling these populations. Furthermore, their habitat often overlaps with that of other amphibian species, necessitating competition and resource partitioning. The Pickerel Frog is also known for its ability to secrete a skin toxin that deters predators.