Pitangus sulphuratus, commonly known as the Great Kiskadee, is native to parts of Central and South America. Its geographical distribution includes countries such as Mexico, Belize, Costa Rica, Panama, Colombia, Venezuela, Brazil, and Argentina. The species can also be found in parts of the southern United States, particularly in Texas and Louisiana, where it has expanded its range.

The Great Kiskadee typically inhabits environments close to water sources, such as riverbanks, lakes, and marshes. It thrives in open woodland, savannas, and areas with scattered trees and shrubs, often near human settlements. The species is adaptable to various climates, ranging from tropical to subtropical conditions, and can be found in both dry and moist environments.

Pitangus sulphuratus occupies the ecological niche of an omnivorous feeder, playing a role in controlling insect and small vertebrate populations. It forages in the canopy and mid-levels of forests as well as in open areas, feeding on insects, fruit, and fish. The Great Kiskadee's distinctive call and behavioral adaptability make it a prominent member of its ecosystem.