Podarcis siculus, commonly known as the Italian wall lizard, is native to the Mediterranean region, particularly found in Italy and the surrounding areas, including nearby islands such as Sicily and Sardinia. It also has a natural presence in parts of the Balkans. Over time, this species has been introduced to various other parts of Europe and North America.

Podarcis siculus thrives in a variety of habitats, typically favoring warm, temperate climates. It is often found in areas with plenty of sunlight and shelter, such as rocky terrain, walls, ruins, and sometimes even urban environments. Their preferred habitats have access to open spaces and small crevices for protection.

The Italian wall lizard occupies an ecological niche as both predator and prey within its food web. It primarily feeds on a wide range of insects and other small invertebrates, which it actively hunts. In turn, it is preyed upon by larger mammals, birds, and other reptiles. The species is known for its adaptability, allowing it to survive in various modified environments.