The Rhinella marina, commonly known as the Cane Toad, is native to Central and South America. Its natural range extends from the Amazon Basin in Peru, eastward across the Amazonas Region of Brazil, and northward to Mexico. It is also found in parts of the southeastern United States and the Caribbean due to introductions.

Rhinella marina thrives in a variety of environments, from tropical rainforests to grasslands, and is capable of adapting to human-altered landscapes such as agricultural fields, gardens, and urban areas. The typical climate in its native range is tropical and semi-tropical, with high humidity and variable precipitation.

This toad occupies a broad ecological niche, often found near bodies of water as they require standing water for breeding. They are generalist feeders, consuming a wide range of invertebrates and small vertebrates. Due to their adaptability, they have minimal specific environmental constraints but prefer warm, moist conditions.